4008S classix
Quality treatment to suit your budget
- Online assessment of dialysis efficiency and dose (OCM®)
- Ultrapure dialysis fluid (DIASAFE®plus)
- Hygienic dry bicarbonate concentrate supply (bibag®)
- AdaptedFlow1 for optimized use of resources
Key features
Assuring quality in operations
Hemodialysis involves a large number of demanding manual operations all around the hemodialysis machine. The ergonomic design and the logical operating structure of the 4008S classix permit easy handling as well as fast and intuitive programming of the treatment parameters. Important treatment values are represented graphically on the 10.4” TFT-LCD monitor, which supports easy comprehension of the ongoing treatment, and provides a fast overview of the treatment history. The Blood Pressure Monitor (BPM) is fully integrated, which further simplifies handling for the therapy providers. In combination with the Therapy Data Management System (TDMS) daily dialysis practice can be organized in a more effective and efficient manner taking full advantage of an online data acquisition and management tool.
In the meantime numerous studies have demonstrated that morbidity and mortality rates are closely correlated to the delivered dialysis dose.2,3 The Online Clearance Monitor (OCM®) enables the continuous monitoring of:
- The effective in-vivo urea clearance (K)
- The accumulated cleared plasma (Kt) or the current dialysis dose administered (Kt/V)
- The plasma sodium concentration: possible deviations to the prescribed therapy goal can be detected and corrected immediately during treatment* without incurring additional expenses for disposables or staff efforts
The non-invasive and precise Kt/V assessment is consistent with conventional blood sample-based methods enabled by urea distribution volume V measured with the BCM-Body Composition Monitor.4
Delivering quality in therapy
The quality and purity of the dialysis fluid are of major concern in modern-day renal replacement therapies, as large volumes of dialysis fluid come into contact with the patient’s bloodstream during each treatment. Endotoxins present in contaminated dialysis fluid may elicit undesirable acute reactions and influence the long-term outcome of patients on chronic hemodialysis. The DIASAFE®plus dialysis fluid filter enables the production of ultrapure dialysis fluid. This is attributed to the excellent endotoxin-retention capabilities of its Fresenius Polysulfone fibers and an intelligent safety concept, based on:
- Functional control of filter integrity
- Automatic surveillance of filter lifetime
- Aseptic connection technology
Ultrapure dialysate fluid is acknowledged to be an integral part of all contemporary dialysis equipment. Naturally the DIASAFE®plus is an essential part of the basic configuration of all current Fresenius Medical Care dialysis machines.
To avoid the potential risk of microbiological contamination through liquid bicarbonate concentrate, the bicarbonate buffer is always supplied as a dry substance. In addition to this excellent hygienic standard, the bibag® is characterized by:
- Easy and ergonomic handling
- Minimum storage space required
- Ecological benefits due to reduced waste volume and less transport weight
Features at a glance
Quality treatment to suit your budget quality
Almost one in two patients with ESRD dies as a result of cardiovascular disease. That is why Cardioprotective Hemodialysis is a core principle of Fresenius Medical Care, as we work and strive to solve the challenges of modern dialysis. Each step we take is focused on minimizing cardiovascular risks and extending patients’ lives. The Next Generation 4008S continues the success story of the well-known 4008 series, by combining best quality HD treatment, proven reliability and operational efficiency.
Proven quality
The latest member of a long established and highly successful 4008 series
- Advanced dialysis fluid circuit with highly-precise volumetrically controlled ultrafiltration
- Consistently reliable hydraulics
Advanced treatment
High-quality HD treatment to protect your patient
- OCM® (Online Clearance Monitor)
- DIASAFE®plus (Dialysis Fluid Filter)
- bibag® (Dry Bicarbonate Concentrate)
- Single needle or SN Click-Clack
- ISO-UF program
Operational efficiency
Cost effective use of resources
- Easy, fast and intuitive handling
- TDMS (Therapy Data Management System)
- BPM (Blood Pressure Monitor)
- CDS (Central Concentrate Delivery System)
- AdaptedFlow1
Performance data
Technical Data 4008S classix
| General data | |
|---|---|
| Dimensions 4008S Weight | 1370 x 500 x 650 mm (H x W x D) (including shunt interlock and pedestal) approx. 86 kg |
| Water supply | |
| Water inlet pressure | 1.5 to 6.0 bar |
| Water inlet temperature | 5°C to 30°C; for “integrated hot rinse” 85°C to 95°C |
| Max. drain height | 1 m |
| Concentrate supply | |
| Supply pressure | 0 to 100 mbar; 1 m max. suction height |
| Central supply | 1 central acid concentrate (optional) 0 to 500 mbar |
| Electrical data | |
| Power supply | 100 to 240 V AC, 50 to 60 Hz |
| Current consumption | Approx. 9 A (at 230 V) and 15 A (at 110 V) |
| External connections | Network interface for data exchange with Therapy Data Management System (optional); input/output for connection of external auxiliary equipment; alarm input/output (e.g. for nurse call); diagnosis for in-house computer diagnosis |
| Battery | 18 V; 3 Ah (maintenance free) |
Extracorporeal circuit
| Extracorporeal circuit | |
|---|---|
| Arterial pressure monitoring | |
| Display range | - 300 mmHg to + 280 mmHg |
| Accuracy | ±10 mmHg |
| Resolution | 20 mmHg |
| Venous pressure monitoring | |
| Display range | - 60 mmHg to + 520 mmHg |
| Accuracy | ±10 mmHg |
| Resolution | 20 mmHg |
| Transmembrane pressure monitoring | |
| Display range | - 60 mmHg to + 520 mmHg |
| Resolution | 20 mmHg |
| Arterial blood pump | |
| Blood flow range | 15 to 600 mL/min |
| Accuracy | ± 10% |
| Resolution | 5 mL/min |
| Single needle system (optional) | With 2 blood pumps, internal pressure/pressure control with variable stroke volume (max. 50 mL/min) |
| Air bubble detector | Ultrasonic transmission measurement on blood line, additional optical monitoring in venous clamp |
| Heparin pump | Delivery range: 0 to 10 mL/h Bolus function: max. 5 mL per bolus Syringe size: 20 mL |
Dialysis fluid circuit
| Dialysis fluid circuit | |
|---|---|
| Dialysis fluid flow range | |
| Selectable | 0 – 300 – 500 – 800 mL/min |
| AdaptedFlow*(selectable) | Dialysate flow adapted to the effective blood flow |
| Dialysis fluid temperature | |
| Selectable | 35°C to 39°C |
| Dialysis fluid conductivity | |
| Range | 12.8 to 15.7 mS/cm (25°C) |
| Accuracy | ± 0.1 mS/cm |
| Resolution | 0.1 mS/cm |
| Dialysis fluid acid component | |
| Mixing ratio | Adjustable, e.g. 1+44, 1+34 |
| Adjustment range | 125 to 150 mmol/L |
| Dialysis fluid bicarbonate component | |
| Default mixing ratio | 1 + 27.6 (others possible) |
| Adjustment range | - 8 to + 8 mmol/L |
| OCM® | Online Clearance Monitoring |
| Accurate Clearance K | ± 6% |
| Bicarbonate dry concentrate | bibag® |
| Dialysis fluid filter system | DIASAFE®plus |
| Balancing accuracy | ± 0.1 % according to the total dialysate volume |
| Pressure holding tests | Cyclic |
| Ultrafiltration | |
| UF rate | 0 to 4000 mL/h (in steps of 1 mL/h) |
| Pump volume accuracy | ± 1% |
| Parameters displayed | UF goal, UF time, UF rate, UF volume |
| Blood leak detector | |
| Sensitivity | ≤ 0.5 mL blood/min (Hct = 25) at max. flow 800 mL/min |
| BPM (optional) | |
| Display range | Systole: 30 mmHg to 280 mmHg |
| Diastole: 10 mmHg to 240 mmHg | |
| MAP: 20 mmHg to 255 mmHg | |
| Pulse: 20 to 245 1/min | |
| Pump volume accuracy | ± 1% |
| Accuracy | ± 3 mmHg |
| Resolution | 1 mmHg |
Disinfection and cleaning programmes**
| Disinfection and cleaning programmes** | |
|---|---|
| Dialysis fluid flow range | |
| Rinse Temperature/flow | 37 °C / 600 mL/min |
| Hot rinse (recirculation) Temperature/flow | 84 °C / 450 mL/min |
| Integrated hot rinse Temperature/flow | 84°C / 450 mL/min |
| Cleaning Sporotal100® (recirculation) Temperature/flow | 37 °C / 600 mL/min |
| Heat disinfection Diasteril®/Citrosteril® (recirculation) Temperature/flow | 84° C / 450 mL/min |
| Disinfection Puristeril® 340/plus (recirculation) Temperature/flow | 37 °C / 600 mL/min |
* Not available in all countries.
** Various programme combinations selectable. Technical changes reserved.
1 Not available in all countries
2 Hakim R, Breyer J, Ismail N, Schulmann G: Effects of dose of dialysis on morbidity and mortality. American Journal of Kidney Diseases (1994); 23:661-669
3 Port F, Ashby V, Dhingra R, Roys E, Wolfe R: Dialysis dose and body mass index are strongly associated with survival in hemodialysis patients. Journal of the American Society of Nephrology (2002); 13:1061-1066
4 Lindley EJ, Chamney PW, Wuepper A, Ingles H, Tattersall JE, Will EJ: A comparison of methods for determining urea distribution volume for routine use in on-line monitoring of hemodialysis adequacy. Nephrology Dialysis Transplantation (2009); 24(1):211-6